The impact of depression on the quality of life and functional capacity of patients with chronic heart failure and a preserved left ventricular ejection fraction

• Dmitriy S. Evdokimov
• Sofya A. Grebennikova
• Anna Yu. Prokhorenko
• Ekaterina D. Resnyanskaya

Abstract

The problems of the relationship between anxiety and depressive disorders and chronic heart failure (CHF) are of great interest to researchers. The reason for this is probably the increasing incidence of these disorders, as well as the high social significance of heart failure.

Objective – to evaluate the impact of depression (DP) on the quality of life and functional state of patients with chronic heart failure with preserved left ventricular ejection fraction (CHFsEF).

Material and methods. The study group included patients with an established diagnosis of CHFsEF. The Hospital Anxiety and Depression Scale (HADS) was used to diagnose DP. All patients underwent standard clinical and laboratory-instrumental examination. The following scales and questionnaires were also used: the scale for assessing the clinical state of a patient with CHF (CHS), the Minnesota Quality of Life Questionnaire, the DEG scale, and the Memorial Symptom Rating Scale.

Results. A total of 43 people with a diagnosis of CHFsEF during hospitalization completed the HADS survey, after which the patients were divided into two groups: group 1 (with DP) – 16 people and group 2 (without DP) – 16 people. According to the Minnesota Questionnaire upon admission to hospital, quality of life was initially significantly lower in the first group (37.5 [13.5–56.5] and 10 [3.5–22.5] respectively; p=0.003). On the DEG scale, the average score upon admission to the hospital was 18 [11–21.5] and 6 [3–16.5], respectively, while in the group with DP the score was significantly higher (p=0.03). According to the results obtained using the Memorial Symptom Rating Scale, the group of patients with DP had a significantly higher score on the PHYS-MSAS subscale. The following direct correlations were also obtained: HADS-SHOCS on admission (r=0.45; p<0.05), HADS-DEG on admission (r=0.53; p<0.05), HADS-MLHFQ on admission (r=0.68; p<0.05), HADS-PHYS-MSAS (r=0.63; p<0.05), HADS-PSYCH-MSAS (r=0.59; p<0.05).

Conclusion. The quality of life, severity of dyspnea and functional status in patients with CHFsEF depend on the presence of DP, which must be taken into account when conducting examinations and appropriate treatment.

Keywords: depression; quality of life; chronic heart failure with preserved left ventricular output fraction

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