The intensity of thrombinogenesis and the activity of the protein C system in patients with coronary artery disease before and after endovascular revascularization postinfarction aneurysm of the left ventricle
AbstractThe resumption of clinical manifestations of coronary artery disease (CAD) after percutaneous coronary intervention (PCI) is observed in more than a third of patients during the first year after revascularization. Among the recurrences causes of the disease after the intervention, changes in the hemostasis system are considered, including those associated with a decrease in the activity of natural anticoagulants, such as protein C.
The aim – to study the nature of non-platelet thrombogenesis, which reflects the state of the plasma-coagulation link of hemostasis and the activity of the protein C system, in patients with coronary heart disease before and after endovascular revascularization.
Material and methods. The material for the study was the venous blood samples of 70 patients with coronary artery disease aged 53 to 75 years, obtained before the primary PCI, 1 day, 2 weeks, 3, 6 and 12 months after the intervention. The state of hemostasis was assessed using a thrombin generation test performed in platelet-poor plasma in two parallel settings: in the presence of human recombinant thrombomodulin (rh-TM) and without it.
Results. The intensity of thrombinogenesis in CAD patients before endovascular intervention does not differ significantly from that in practically healthy people; in patients with CAD in the early postoperative period, as well as 6 and 12 months after endovascular revascularization, there is a decrease in the activity of the protein C system and an increase in thrombinogenesis.
Conclusion. A decrease in the activity of the protein C system at various times after the intervention is a feature of thrombogenesis not associated with platelets in patients with CAD who underwent endovascular revascularization.
Keywords:сoronary artery disease; endovascular revascularization; thrombin generation test; thrombinogenesis; protein C
Funding. The study had no sponsor support.
Conflict of interest. The authors declare no conflict of interest.
Authors’ contribution. Authors contributed equally to the writing of the article.
For citation: Berezovskaya G.A., Petrishchev N.N., Lazovskaya T.V., Yakovlev A.N., Karpenko M.A., Khalimov Yu.Sh. The intensity of thrombinogenesis and the activity of the protein C system in patients with coronary artery disease before and after endovascular revascularization. Kardiologiya: novosti, mneniya, obuchenie [Cardiology: News, Opinions, Training]. 2023; 11 (3): 7–14. DOI: https://doi.org/10.33029/2309-1908-2023-11-3-7-14 (in Russian)
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