PCSK-9: modern views about biological role and possibilities of use as a diagnostic marker for cardiovascular diseases. Part 2
AbstractThis part of our review is devoted to the discussion of the possibility of using proprotein convertase subtiLisin/Kexin type-9 (PCSK-9) as a biomarker for the detection of Lipid metabolism disorders and atherosclerotic Lesions, which are an integral part of cardiovascular diseases. PCSK-9 concentrations are associated (correlated) with metabolic parameters (total cholesterol, low-density lipoproteins, triglycerides, glucose, γ-gamma-glutamyltransferase), vascular changes, body mass index, age, sex. Levels of PCSK-9 depend on many factors: the method of determination (type of antibodies used in immunoassay), lipid-lowering therapy (statins, fibrates), comorbidities (renal failure, diabetes, hypothyroidism, obesity, inflammatory diseases), diet, gender, circadian, age-sex and race-population characteristics.
Keywords:proprotein convertase subtilisin/Kexin type-9 (PCSK-9), PCSK-9 concentration, cholesterol, low density lipoproteins, triglycerides, diabetes mellitus, insulin, glucose, natriuretic peptides, cardiovascular disease, hypercholesterolemia, renal failure, body mass index, statins, fibrates
For citation: Chaulin A.M., Duplyakov D.V. PCSK-9: modern views about biological role and possibilities of use as a diagnostic marker for cardiovascular diseases. Part 2. Kardiologiya: novosti, mneniya, obuchenie [Cardiology: News, Opinions, Training]. 2019; 7 (4): 24-35. doi: 10.24411/2309-1908-2019-14004 (in Russian)