PCSK-9: modern views about biological role and possibilities of use as a diagnostic marker for cardiovascular diseases. Part 2

• Duplyakov Dmitriy V.
• Chaulin Aleksey M.

Abstract

This part of our review is devoted to the discussion of the possibility of using proprotein convertase subtiLisin/Kexin type-9 (PCSK-9) as a biomarker for the detection of Lipid metabolism disorders and atherosclerotic Lesions, which are an integral part of cardiovascular diseases. PCSK-9 concentrations are associated (correlated) with metabolic parameters (total cholesterol, low-density lipoproteins, triglycerides, glucose, γ-gamma-glutamyltransferase), vascular changes, body mass index, age, sex. Levels of PCSK-9 depend on many factors: the method of determination (type of antibodies used in immunoassay), lipid-lowering therapy (statins, fibrates), comorbidities (renal failure, diabetes, hypothyroidism, obesity, inflammatory diseases), diet, gender, circadian, age-sex and race-population characteristics.

Keywords:proprotein convertase subtilisin/Kexin type-9 (PCSK-9), PCSK-9 concentration, cholesterol, low density lipoproteins, triglycerides, diabetes mellitus, insulin, glucose, natriuretic peptides, cardiovascular disease, hypercholesterolemia, renal failure, body mass index, statins, fibrates

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