Adenosine and its role in the physiology and pathology of the cardiovascular system

• Chaulin Aleksey M.

Abstract

Adenosine is an endogenous purine nucleoside with short half-life and regulates many physiological functions, including functions of the cardiovascular system. In this review effects of adenosine on cardiac electrophysiologic properties and diagnostic and treatment options for arrhythmias are represented. The effects of adenosine on vascular endothelium, smooth muscle cells, inflammatory response and metabolic processes under normal and pathological conditions are discussed. Furthermore influence of adenosine on vascular-platelet link of hemostasis is also highlighted.

Keywords:adenosine, cardiovascular system, adenosine receptors, metabolism, hemostasis

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