Adipokines and echocardiographic parameters in men with diabetes mellitus type 2 and hypothyroidism

• Andrey F. Verbovoy
• Lyudmila A. Sharonova
• Tatyana V. Lomonova

Abstract

Aim - to assess the relationship between adipokines and echocardiographic parameters in patients with type 2 diabetes and hypothyroidism.

Material and methods. We examined 20 men aged 38 to 64 years who were divided into 2 groups. The 1^st group included 10 patients with hypothyroidism, the 2^nd group consisted of 10 men with diabetes type 2. For all patients were measured anthropometry, studied indicators of lipid and carbohydrate metabolism, the content of leptin, adiponectin, resistin. All patients underwent echocardiography of the heart.

Results. In men with hypothyroidism, an increase in the level of insulin, total cholesterol, triglycerides was detected. Men with diabetes mellitus type 2 had hyperglycemia and hyperinsulinemia, as well as an increase in total cholesterol, triglycerides, low-density lipoprotein cholesterol, and a decrease in high-density lipoprotein cholesterol. All the patients examined showed an increase in leptin concentration and a decrease in the concentration of adiponectin. Thickness of interventricular septum in systole, interventricular septum in diastole, the posterior wall of the left ventricular in diastole, myocarduial mass of the left ventricle, myocardial mass index of the left ventricle, the size of the left atrium and the right ventricle were increased in all patients.

Conclusion. In men with diabetes type 2, visceral obesity was associated with insulin resistance, which was accompanied by compensatory hyperinsulinemia. There were identified hyperinsulinemia and increased insulin resistance in men with hypothyroidism. In men with diabetes type 2 and hypothyroidism, atherogenic dyslipidemia, hypoadiponectinemia, hyperleptinemia as well as left ventricular hypertrophy, diastolic dysfunction in intact ventricular myocardial contractility were detected. Hyperleptinemia and hypoadiponectinemia may be involved in the process of myocardial remodeling in these patients.

Keywords:atrial fibrillation, acute coronary syndrome, antithrombotic therapy, oral anticoagulants, hemorrhagic syndrome

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