Antiplatelet therapy in patients with atrial fibrillation on the background of acute coronary syndrome in real clinical practice according to the total register of acute coronary syndrome in the Krasnodar Territory

• Tatarintseva Z.G.
• Kosmacheva E.D.
• Kruchinova S.V.
• Porkhanov V.A.

Abstract

The aim of the study was to evaluate in patients with atrial fibrillation (AF) who underwent acute coronary syndrome (ACS), the frequency of appointment of oral anticoagulant therapy (UAC) prior to the ACS episode, adherence of patients to OAB after 6-24 months after the ACS episode ACS for the Krasnodar Territory. An attempt was also made to identify the relationship between the volume of antithrombotic therapy used and the development of hemorrhagic complications. A retrospective analysis of the case histories of 13 244 patients admitted to the infarction departments of all the settlements of Krasnodar Region without exception and included in the ACS registry for the Krasnodar Territory from November 20, 2015 to November 20, 2017 was conducted. From this cohort of patients, 1204 (9%) patients of ACS were accompanied by AF. From the register were taken for analysis patients consistently enrolled in the cardiology departments of Research Institute - prof. S.V. Ochapovsky Regional Clinical Hospital #1, from November 20, 2015 to February 20, 2018 with the diagnosis of ACS, accompanied by one of the types of atrial fibrillation (paroxysmal, persistent or persistent). This group consisted of 201 patients. Analysis of the frequency of use of antithrombotic agents in patients with ACS and AF in the Krasnodar Krai registry revealed a low incidence of OAB use in patients with AF prior to development of ACS (10.45%), a low percentage of prescription of OAB after discharge from hospital (62.78%), which decreases in proportion to the increase in time since the ACS (52.29%), a high percentage of hemorrhagic complications in the triple antithrombotic therapy (TAT) background (26.74%).

Keywords: atrial fibrillation, acute coronary syndrome, antithrombotic therapy, oral anticoagulants, hemorrhagic syndrome

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