Renoprotective effects of statins

• Koshelev N.A.
• Mel'dina Yu.N.
• Rebrov Andrey P.

AbstractStatins are used for treating hyperlipidemia. Apart from cholesterol-lowering effects, statins possess antiinflammatory and antioxidant action, affect endothelial function, reduce vessel smooth muscle cell proliferation and thrombocyte aggregation. Those effects provide the possibility of wider application of statins, particularly renoprotection. There is evidence of a positive effect of statins on kidney function in chronic kidney disease and acute kidney injury. We present a review of the literature highlighting the arguments for and against the use of statins for the prevention and treatment of these conditions.

Keywords:statins, chronic kidney disease, acute kidney injury, contrast-induced nephropathy

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