The influence of anticoagulant therapy on oxygenation of erythrocyte membranes in correlation with the parameters of microcirculation in patients with atrial fibrillation

• Zolotovskaia Irina A.
• Davydkin Igor L.
• Duplyakov Dmitriy V.
• Larisa V. Limareva
• Sustretov A.S.

Abstract

The aim of the work was to study the effect of anticoagulant therapy on the oxygenation of erythrocyte membranes in conjunction with microcirculation in patients with atrial fibrillation (AF).

Material and methods. A one-stage study with sequential inclusion of patients with AF, after cardioembolic stroke (CEI). Patients are divided into two groups: group 1 (n=50), included patients taking anticoagulants, patients who did not take anticoagulants - group 2 (n=50). Parameters of erythrocyte membrane, including erythrocyte membrane oxygenation index (dy2/dy1) using laser interference microscopy method. Studied parameters of the microcirculation by laser Doppler flowmetry.

Results. In patients of group 2, a statistically significant (p=0.001) low dy2/dy1 value was observed with a corellation index reflecting the oxygen saturation degree of microcurrent (Sm) (r=-0.66; p=0.028).

Summary. The results showed the advantage of anticoagulant therapy on the indices of microcirculatory status and the degree of oxygenation of erythrocytes in patients with AF.

Keywords:atrial fibrillation, cardioembolic stroke, microcirculation, oxygenation of erythrocyte membranes, stiffness of red blood cells, anticoagulant therapy

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