Age dynamics of integral circulatory parameters in patients without severe somatic pathology
AbstractThe work is devoted to the study of central hemodynamics integral indices in patients without severe somatic pathology with normal arterial pressure and preserved contractile function of left ventricle myocardium in the age aspect.
Aim: to study the integral parameters of blood circulation, including the integral rigidity of the arterial system in patients with normal arterial pressure and preserved contractile function of the left ventricle myocardium depending on the age.
Material and methods. The study included 1283 patients aged from 18 to 91, 41.2±18.3 years. Among them, 799 women (62.3%), mean age 46.4±18.3 years and men 484 (37.7%), mean age 43.2±18.2 years. All patients underwent echocardioscopy. HR, SV, CO, systolic and diastolic blood pressure were determined. According to the mathematical model the modulus of volume elasticity (MVE), total peripheral vascular resistance (TPVR), MVE/TPVR and mean arterial pressure were calculated.
Results. It was shown that with an increase in age, TPVR, MVE and pulse blood pressure (PBP) increase. The parameters of SV and CO did not change significantly with increase of age. In women, TPVR, MVE, MVE/TPVR were higher than in men.
Conclusions. In patients with normal arterial pressure and without severe somatic pathology, an increase in the integral stiffness of the arterial system is observed with increase of age. At a young age, women have higher values of the integral stiffness of the arterial system than men. In men, an earlier increase of the arterial system stiffness (from age 40) is observed, than in women (from age 60). In the elderly and senile age there are no statistical differences in the rates of arterial stiffnessin men and women.
Keywords:arterial system integral
stiffness, central hemodynamics, age-related changes in hemodynamics
DOI: 10.24411/2309-1908-2017-00004