Role of melatonin in patients with acute coronary syndrome

• Mikhailova Zinaida D.
• Shalenkova Maria A.

AbstractThe available data on melatonin production in acute coronary syndrome are known to be contradictory. Its role in the human body is not quite clear either. However, some of its properties have been convincingly proved. Melatonin has been shown to produce vivid effect on arterial pressure level and myocardium contractility, to inhibit apoptosis and thrombocyte aggregation, to slow down cardiac contraction rate, to control pain syndrome, to diminish myocardium dimensions, to reduce the incidence and severity of ventricular arrhythmia and to decrease cardio-vascular lethality. Melatonin low levels were found to predict remodeling of left ventricle after myocardium infarction and to prevent fibrosis affecting each of its 4 stages. Melatonin is gaining its attractivity in medical practice due to its atoxicity and a number of its potential activities such as biorhythmologic, antioxidant, immune-modulating, vasodilatative, anti-aggregant, antiarrhythmic, antianxiety, antidepressant and hypnogenic.

Keywords:melatonin, acute coronary syndrome

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