Prognostic value of late gadolinium enhancement in nonischemic cardiomyopathy

• Gaztanaga Juan
• Paruchuri Vijayapraveena
• Elias Elliott
• Wilner Jonathan
• Islam Shahidul
• Sawit Simonette
• Viles-Gonzalez Juan
• Sanz Javier
• Garcia Mario J.

Abstract

The purpose of this study was to determine the prognostic value of late gadolinium enhancement seen on cardiac magnetic resonance (CMR) imaging in patients with nonischemic cardiomyopathy (NICMP). Patients with NICMP are at increased risk for cardiovascular events and death. The presence of late gadolinium enhancement (LGE) in CMR may be associated with a poor prognosis, but its significance is still under investigation. We retrospectively studied 105 consecutive patients with NICMP and left ventricular ejection fraction (LV EF) ≤40% referred for CMR. The cohort was analyzed for the presence of LGE and left and right ventricular functional parameters. Patients were followed for the composite end point of hospitalization for congestive heart failure, appropriate implantable cardioverter-defibrillator therapy, or all-cause mortality. LGE was observed in 71 (68%) of the cohort. Both groups were similar in age, LV EF and LV end-diastolic volume. The LGED patients were more often men and had larger right ventricular volumes. At a mean follow-up of 806+582 days, there were 26 patients (23 in the LGEDgroup) who reached the primary end point. Event-free survival was significantly worse for the LGED patients. After adjusting for traditional risk factors (age, gender, LVEF), patients with LGE had an increased risk of experiencing the primary end point (hazard ratio 4.47, 95% CI 1.27 to 15.74, p=0.02). The presence of LGE in patients with NICMP strongly predicts the occurrence of adverse events. In conclusion, this may be important in risk stratification and management.