Dynamics of prescribing of oral anticoagulants to outpatients with atrial fibrillation during 2012 - 2016 according to the Registry of cardiovascular diseases

• Pereverzeva K.G.
• Moseichuk K.A.
• Vorobyev A.N.
• Loukianov M.M.
• Zagrebelnyi A.V.
• Kharlap M.S.
• Yakushin S.S.

Abstract

Aim - to assess the dynamics of prescribing of oral anticoagulants (OACs) in outpatients with atrial fibrillation (AF) during 2012 - 2016 according to RECVASA registry.

Material and methods. RECVASA registry included patients over 18 years old with hypertension, coronary heart disease, chronic heart failure, AF and their combinations, who made a visit to a therapeutist or cardiologist due to cardiovascular disease in three randomly selected outpatient clinics in Ryazan region in 2012-2013. 530 patients with AF were included in total. Afterwards a representative sample of patients with atrial fibrillation (n=112) was formed, in whom the rate of prescribing of OACs was assessed in 2012-2016.

Results. In the analyzed sample in 2012 OACs were prescribed in 5.4% of cases, including warfarin in 4.5% of cases and novel oral anticoagulants (NOACs) in 0.9%. During the follow-up from 2012 till December 2016 there was a statistically significant increase in OACs prescription rate to 27.3% (р=0.0001) with NOACs prescription rate of 7.1% (р=0.025) and warfarin of 20.2% (р=0.0005).

Conclusions. According to the registry of cardiovascular diseases in patients with AF who have a high risk of embolic events, in 2012 OACs were prescribed only to 5.4% of patients. During the four years of follow-up the OACs prescription rate increased to 27.3% (р=0.0001) due to 4.5-fold increase of warfarin prescription rate and 7.9-fold increase of NOACs prescription rate.

Keywords:oral anticoagulants, warfarin, atrial fibrillation, outpatient register, cardiovascular diseases

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