Optimization of the approach to determining the dilatation of the aortic root in congenital connective tissue disorders

• E.V. Semenova
• Semenkin A.A.
• Chindareva O.I.
• Makhrova N.V.
• G.I. Nechaeva
• Potapov V.V.
• Zhivilova L.A.
• Loginova E.N.

Abstract

Dilatation of the aortic root occurs in many diseases with involvement of the cardiovascular system, including the connective tissue disorders, syndromes and non-syndrome forms (NSCTD). There are not a lot of clinical data about the frequency of aortic root enlargement at NSCTD. Thus, according to some studies in patients with NDCTD aortic root dilatation occurs in about 10% of cases.

The aim of our study was to assess the effectiveness of the conventional algorithm for determining the dilatation of the aortic root by echocardiography (echocardiography) in patients with NSCTD and optimization approach to determining normal values for this parameter.

The study included 372 healthy volunteers, men and women aged 15 to 65 years, including patients with NSCTD (n=184) and without the pathology (n=188) identified on the basis of external and internal systemic features of congenital connective tissue disorders. All patients underwent clinical examination, echocardiography, calculation of the normal aortic root diameter and Z-test according to the method Roman M.J. et al. (1989).

The study results confirmed that aortic root enlargement may be found in a proportion of patients with NSCTD. Currently existing conventional algorithms underestimate the changes in the aortic root in both healthy individuals as well as in patients with NDCTD. For a more accurate calculation of normal values of the aortic root diameter can be used regression model obtained in our study, which takes into account gender, age and body surface area.

Keywords:aortic root, dilatation, congenital connective tissue disorders

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