To the content
2 . 2022

Growth differentiation factor 15, treatment with liraglutide, and clinical outcomes among patients with heart failure

Abstract

Aims. Associations between growth differentiation factor‑15 (GDF‑15), cardiovascular outcomes, and exercise capacity among patients with a recent hospitalization for heart failure (HHF) and heart failure with reduced ejection fraction (HFrEF) are unknown. We utilized data from the ‘Functional Impact of GLP‑1 for Heart Failure Treatment’ (FIGHT) study to address these knowledge gaps.

Methods and results. FIGHT was a randomized clinical trial testing the effect of liraglutide (vs. placebo) among 300 participants with HFrEF and a recent HHF. Multivariable regression models evaluated associations between baseline GDF‑15 and change in GDF‑15 (per 1000 pg/mL increase from baseline to 30 days) with clinical outcomes (at 180 days) and declines in exercise capacity (6 min walk distance ≥45 m). At baseline (n=249), median GDF‑15 value was 3221 pg/mL (interquartile range 1938–5511 pg/mL). Participants in the highest tertile of baseline GDF‑15 were more likely to be male and have more comorbidities.

After adjustment, an increase in GDF‑15 over 30 days was associated with higher risk of death or HHF [hazard ratio 1.35, 95% confidence interval (CI) 1.11–1.64]. In addition, higher baseline GDF‑15 (per 1000 pg/mL until 6000 pg/mL) and an increase in GDF‑15 over 30 days were associated with declining 6 min walk distance (odds ratio 1.26, 95% CI 1.02–1.55 and odds ratio 1.37, 95% CI 1.12–1.69, respectively). GDF‑15 levels remained stable among participants randomized to liraglutide.

Conclusions. An increase in GDF‑15 over 30 days among patients in HFrEF was independently associated with an increased risk of cardiovascular events and declining exercise capacity. These results support the value of longitudinal GDF‑15 trajectory in informing risk of heart failure disease progression.

Keywords:GDF-15; heart failure; liraglutide; GLP-1 receptor agonist

Sharma A., Greene S., Muthiah V., Fudim M., Ambrosy A.P., Sun J.-L., McNulty S.E., Hernandez A.F., Borlaug B.A., Velazquez E.J., Mentz R.J., DeVore A.D., Alhanti B., Margulies K., Felker G.M. Growth differentiation factor‑15, treatment with liraglutide, and clinical outcomes among patients with heart failure. ESC Heart Failure. 2021; 8: 2608–16.

DOI: https://www.doi.org/10.1002/ehf2.13348

CHIEF EDITOR
CHIEF EDITOR
Andrey G. Obrezan
MD, Professor, Head of the Hospital Therapy Department of the Saint Petersburg State University, Chief Physician of SOGAZ MEDICINE Clinical Group, St. Petersburg, Russian Federation
Вскрытие
МКК
Medicine today

Съезд хирургов ФМБА России " Высокотехнологичная медицинская помощь: концепция безопасности и единого хирургического пространства " 14-15 октября 2022 года, г. Санкт-Петербург Впервые в истории хирургическая безопасность будет изучена столь подробно! Отныне "S afe surgery "...

Председатель организационного комитета 17-го Национального конгресса терапевтов - министр здравоохранения Российской Федерации - Михаил Альбертович Мурашко В программе конгресса запланированы более 150 образовательных секций, симпозиумов, клинических разборов, мастер-классов...

Уважаемые коллеги! Представляем оргкомитет 17-го Национального конгресса терапевтов (с международным участием) , который состоится 12-14 октября в МВЦ "Крокус Экспо" (павильон 3, Зал 20, г. Москва). · Президент Российского научного медицинского общества терапевтов,...


Journals of «GEOTAR-Media»