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1 . 2021

Therapeutic effects of triple antiplatelet therapy in elderly female patients with diabetes and acute myocardial infarction

Abstract

Background. Dual antiplatelet therapy (DAPT) is the cornerstone treatment of acute myocardial infarction (AMI).

Objective. The present study aimed to investigate the efficacy and safety of triple antiplatelet therapy (TAPT) in elderly female patients with diabetes and ST segment elevation myocardial infarction (STEMI), who had undergone percutaneous coronary intervention (PCI).

Methods. We designed a randomized, single-blind study. Control group A (97 elderly male patients with diabetes and STEMI, whose CRUSADE scores were <30) received aspirin, ticagrelor, and tirofiban. A total of 162 elderly female patients with diabetes and STEMI were randomly divided into two groups according to CRUSADE score. Group B (69 patients with CRUSADE score >31) received aspirin and ticagrelor. Group C (93 patients with CRUSADE score <30) received aspirin, ticagrelor and tirofiban. P-values <0.05 were considered statistically significant.

Results. Compared to the findings in group A, post-PCI Thrombolysis in Myocardial Infarction (TIMI) grade 3 blood flow and TIMI myocardial perfusion grade 3 were significantly less prevalent in group B (p<0.05). When compared to groups A and C, the incidence of major adverse complications was significantly higher in group B (p<0.05).

Conclusion. TAPT could effectively reduce the incidence of major complications in elderly female patients with diabetes and STEMI. However, close attention should be paid to hemorrhage in patients receiving TAPT.

Keywords:platelet aggregation, stroke, woman, aging, diabetes mellitus, myocardial infarction, percutaneous coronary intervention/methods

Liu Y., Gao Y., Liu H., Chen Q., Ji J., Jia K. Therapeutic effects of triple antiplatelet therapy in elderly female patients with diabetes and acute myocardial infarction. Arq. Bras. Cardiol. 2021; 116 (2): 229–235. DOI: https://doi.org/10.36660/abc.20190442

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CHIEF EDITOR
CHIEF EDITOR
Andrey G. Obrezan
MD, Professor, Head of the Hospital Therapy Department of the Saint Petersburg State University, Chief Physician of SOGAZ MEDICINE Clinical Group, St. Petersburg, Russian Federation
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